Protosappanin‐A and oleanolic acid protect injured podocytes from apoptosis through inhibition of AKT‐mTOR signaling
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Radiosensitizing effect of oleanolic acid on tumor cells through the inhibition of GSH synthesis in vitro.
Oleanolic acid (OA) is a natural pentacyclic triterpenoid that has been used in traditional medicine as an anticancer and anti-inflammatory agent. The aim of our study was to investigate whether or not OA increases the radiosensivity of tumor cells, and the relative mechanism was also investigated. Clonogenic assay was used to observe the radiosensitivity of C6 and A549 cells following differen...
متن کامل9-cis-Retinoic Acid and 1,25-dihydroxy Vitamin D3 Improve the Differentiation of Neural Stem Cells into Oligodendrocytes through the Inhibition of the Notch and Wnt Signaling Pathways
Background: Differentiating oligodendrocyte precursor cells (OPCs) into oligodendrocytes could be improved by inhibiting signaling pathways such as Wnt and Notch. 9-cis-retinoic acid (9-cis-RA) and 1,25-dihydroxyvitamin D3 (1,25[OH]2D3) can ameliorate oligodendrogenesis. We investigated whether they could increase oligodendrogenesis by inhibiting the Wnt and Notch signaling pathways.Methods: Co...
متن کاملPharmacology of oleanolic acid and ursolic acid.
Oleanolic acid and ursolic acid are triterpenoid compounds that exist widely in food, medicinal herbs and other plants. This review summarizes the pharmacological studies on these two triterpenoids. Both oleanolic acid and ursolic acid are effective in protecting against chemically induced liver injury in laboratory animals. Oleanolic acid has been marketed in China as an oral drug for human li...
متن کاملIsolation and Quantificative Analysis of Oleanolic Acid from Satureja mutica Fisch. & C. A. Mey.
Background: Satureja mutica (Lamiaceae) is an herbaceous plant which grows in North-West of Iran. Oleanolic acid has been previously isolated from some Lamiaceae genus and showed a broad range of biological activities. Besides Silphium spp., Panax quinquefolium root and Calendula officinalis flower as the interesting source of oleanolic acid used in the herbal industry, here we report the iso...
متن کاملComparison of the inhibition capability of oleanolic acid and betulinic acid towards drug-metabolizing enzymes.
BACKGROUND Human UDP-glucuronosyltransferases (UGTs) are important membrane proteins located in endoplasmic reticulum, and play important roles in metabolism of a variety of endogenous and exogenous compounds. AIMS To determine the influence of subtle difference in the structure of oleanolic acid and betulinic acid towards the inhibition towards the activity of UGT isoforms. METHODS In vitr...
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ژورنال
عنوان ژورنال: Cell Biology International
سال: 2019
ISSN: 1065-6995,1095-8355
DOI: 10.1002/cbin.11218